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Assessment of arterial distensibility by automatic pulse wave velocity
measurement. Validation and clinical application studies. Hypertension,
- Low molecular weight heparins : a guide to their optimum use in pregnancy.
Drugs, 2002. 62:463-477.
Influence of L-NAME, acetylcholine
and adenosine on mean blood pressure, pulse pressure and pulse pressure amplification
in rats. Journal of Cardiovascular Pharmacology, 2003.
- Heart rate and pulse pressure
amplification in hypertensive subjects. American Journal of Hypertension
- Gender influence on the relation
between heart rate and aortic stiffness. Journal of Hypertension
- Pulse pressure and arterial
stiffness in rats: comparison with humans. American Journal of
Physiology - Heart and Circulatory Physiology, 2003. 285(4):H1363-9.
Albaladejo P, Laurent
P, Pannier B, Achimatos A, Safar M.E, Benetos
A. Gender influence on the relation
between heart rate and aortic stiffness.
J Hypertens 2003. 21:555-562
Heart rate and aortic pulse wave velocity (PWV) are both cardiovascular
risk factors. The aim of this study was to evaluate the influence of
sex on the heart rate-PWV relationship in two populations of normotensive
and hypertensive men and women.
METHODS : In a first study, steady-state data describing
the heart rate-PWV relationship were determined in 558 normotensive
men, 308 normotensive women, 323 hypertensive men and 93 hypertensive
women. In a second study, the changes in blood pressure and PWV under
atrial pacing at 60, 80 and 100 beats/min were investigated in 15 men
and 15 women who were either normotensive or hypertensive.
RESULTS : In women
in study 1, 26.8% of PWV variance in normotensive patients and 15.4%
of PWV variance in hypertensive patients was explained by a multiple
regression including only age and systolic blood pressure as covariates.
In men in study 1, 27% of PWV variance in normotensive patients and
28.5% of PWV variance in hypertensive patients was explained by a multiple
regression including age, systolic blood pressure, weight, and also
heart rate, as covariates. In study 2, atrial pacing in the overall
population tended to decrease mean blood pressure (P = 0.05) and increase
pulse pressure (P = 0.003), with no substantial change in PWV. However,
when heart rate increased, PWV tended to decrease in women and to increase
in men (interaction: P = 0.07).
CONCLUSION : Accelerated
heart rate influences PWV in both normotensive and hypertensive men
and, through this mechanism, could influence cardiovascular risk.
However, heart rate does not influence PWV in women.
last modified on : 25 oct 2005