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Assessment of arterial distensibility by automatic pulse wave velocity
measurement. Validation and clinical application studies. Hypertension,
1995. 26:485-490.
- Low molecular weight heparins : a guide to their optimum use in pregnancy.
Drugs, 2002. 62:463-477.
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Influence of L-NAME, acetylcholine
and adenosine on mean blood pressure, pulse pressure and pulse pressure amplification
in rats. Journal of Cardiovascular Pharmacology, 2003.
41:210-8.
- Heart rate and pulse pressure
amplification in hypertensive subjects. American Journal of Hypertension
2003. May;16(5):363-70.
- Gender influence on the relation
between heart rate and aortic stiffness. Journal of Hypertension
2003. 21:555-562
- Pulse pressure and arterial
stiffness in rats: comparison with humans. American Journal of
Physiology - Heart and Circulatory Physiology, 2003. 285(4):H1363-9.
Albaladejo P, Laurent
P, Pannier B, Achimatos A, Safar M.E, Benetos
A. Gender influence on the relation
between heart rate and aortic stiffness.
J Hypertens 2003. 21:555-562
Abstract :
Heart rate and aortic pulse wave velocity (PWV) are both cardiovascular
risk factors. The aim of this study was to evaluate the influence of
sex on the heart rate-PWV relationship in two populations of normotensive
and hypertensive men and women.
PATIENTS AND
METHODS : In a first study, steady-state data describing
the heart rate-PWV relationship were determined in 558 normotensive
men, 308 normotensive women, 323 hypertensive men and 93 hypertensive
women. In a second study, the changes in blood pressure and PWV under
atrial pacing at 60, 80 and 100 beats/min were investigated in 15 men
and 15 women who were either normotensive or hypertensive.
RESULTS : In women
in study 1, 26.8% of PWV variance in normotensive patients and 15.4%
of PWV variance in hypertensive patients was explained by a multiple
regression including only age and systolic blood pressure as covariates.
In men in study 1, 27% of PWV variance in normotensive patients and
28.5% of PWV variance in hypertensive patients was explained by a multiple
regression including age, systolic blood pressure, weight, and also
heart rate, as covariates. In study 2, atrial pacing in the overall
population tended to decrease mean blood pressure (P = 0.05) and increase
pulse pressure (P = 0.003), with no substantial change in PWV. However,
when heart rate increased, PWV tended to decrease in women and to increase
in men (interaction: P = 0.07).
CONCLUSION : Accelerated
heart rate influences PWV in both normotensive and hypertensive men
and, through this mechanism, could influence cardiovascular risk.
However, heart rate does not influence PWV in women.
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last modified on : 25 oct 2005 |
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