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Assessment of arterial distensibility by
automatic pulse wave velocity measurement. Validation and clinical
application studies. Hypertension,
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Journal of Physiology - Heart and Circulatory Physiology, 2003.
Asmar R, Benetos A, Topouchian JP, Laurent
P, Pannier B, Brisac AM,
Target R, Levy BI. Assessment
of arterial distensibility by automatic pulse wave velocity measurement.
Validation and clinical application studies. Hypertension
Pulse wave velocity is widely used as an index
of arterial distensibility. The aim of this study was to evaluate
the accuracy of a new automatic device to measure it and then to
analyze the major determinants of pulse wave velocity by application
of this device in a large population. We evaluated the accuracy of
on-line and computerized measurement of pulse wave velocity using
an algorithm based on the time-shifted and repeated linear correlation
calculation between the initial rise in pressure waveforms compared
with the reference method (manual calculation) in 56 subjects. The
results, analyzed according to the recommendations of Bland and Altman,
showed a mean difference of -0.20±0.45
m/s for the mean carotid-femoral pulse wave velocity values (reference
method, 11.05±2.58 m/s; automatic device, 10.85±2.44
The inter-reproducibility and intrareproducibility of measurements
by each method were analyzed with the use of the repeatability coefficient
according to the British Standards Institution. The interobserver repeatability
coefficient was 0.947 for the manual method and 0.890 for the automatic,
and intraobserver repeatability coefficients were 0.938 and 0.935,
We evaluated the major determinants of the
carotid-femoral pulse wave velocity measured by the automatic method
in a separate study performed in 418 subjects of both sexes without
any cardiovascular treatment or complication (18 to 77 years of age;
98 to 222 mm Hg systolic and 62 to 130 mm Hg diastolic pressure).
Multiple regression analysis between pulse wave velocity and clinical
parameters (age, sex, weight, height, smoking, arterial blood pressure,
heart rate) and biological plasma parameters (total cholesterol,
high-density lipoprotein cholesterol, glycemia) showed that pulse
wave velocity correlated positively and independently with age and
systolic pressure (r2=.47; P<.001) according
to the equation Pulse Wave Velocity=0.07 Systolic Pressure (mm Hg)+0.09
Age (y)-4.3 (m/s). Similar results were obtained in the normotensive
and hypertensive subgroups when analyzed separately.
Pulse wave velocity can be easily and automatically determined. Its measurement
is accurate and highly reproducible, and its major determinants are well
established. It is of great interest to evaluate in large populations
the therapeutic and epidemiological applications of an arterial parameter
as evaluated by aortic pulse wave velocity.
last modified on : 25 oct 2005