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- Assessment of arterial distensibility by automatic pulse wave velocity measurement. Validation and clinical application studies. Hypertension, 1995. 26:485-490.
- Low molecular weight heparins : a guide to their optimum use in pregnancy. Drugs, 2002. 62:463-477.
- Influence of L-NAME, acetylcholine and adenosine on mean blood pressure, pulse pressure and pulse pressure amplification in rats. Journal of Cardiovascular Pharmacology, 2003. 41:210-8.
- Heart rate and pulse pressure amplification in hypertensive subjects. American Journal of Hypertension 2003. May;16(5):363-70.
- Gender influence on the relation between heart rate and aortic stiffness. Journal of Hypertension 2003. 21:555-562
- Pulse pressure and arterial stiffness in rats: comparison with humans. American Journal of Physiology - Heart and Circulatory Physiology, 2003. 285(4):H1363-9.

Safar M.E, Laurent P. Pulse pressure and arterial stiffness in rats: comparison with humans. Am J Physiol Heart Circ Physiol. 2003. 285(4):H1363-9.

Abstract :

In the past, hypertensive rats and men were described with a similar hemodynamic pattern involving a proportional increase of systolic (S) and diastolic (D) blood pressure (BP). Nowadays, the enhanced frequency of systolic hypertension in humans suggests to reinvestigate the classical similarities and differences between spontaneously hypertensive rats (SHR) and hypertensive humans.

Old hypertensive rats, with some exception over 50 weeks of age, never develop systolic hypertension. The possible explanation is that, despite the development of a pressure-independent increase of large artery stiffness, a parallel decrease of stroke volume occurs and precedes congestive heart failure.

Several mechanisms contribute to alter the mechanical arterial properties in old SHR: endothelial nitrite oxide deficiency and impaired oxidative stress; development of extracellular matrix, particularly under the influence of angiotensin II, aldosterone and end-glycosyl products; increased sodium intake and sensitivity under specific genetic influences.

Both in humans and rats, these factors contribute to increase arterial stiffness, SBP and pulse pressure with age, thus reducing cardiovascular longevity and suggesting to develop novel therapeutic approaches in humans.

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