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Assessment of arterial distensibility by automatic pulse wave velocity
measurement. Validation and clinical application studies. Hypertension,
1995. 26:485-490.
- Low molecular weight heparins : a guide to their optimum use in pregnancy.
Drugs, 2002. 62:463-477.
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Influence of L-NAME, acetylcholine
and adenosine on mean blood pressure, pulse pressure and pulse pressure amplification
in rats. Journal of Cardiovascular Pharmacology, 2003.
41:210-8.
- Heart rate and pulse pressure
amplification in hypertensive subjects. American Journal of Hypertension
2003. May;16(5):363-70.
- Gender influence on the relation
between heart rate and aortic stiffness. Journal of Hypertension
2003. 21:555-562
- Pulse pressure and arterial
stiffness in rats: comparison with humans. American Journal of
Physiology - Heart and Circulatory Physiology, 2003. 285(4):H1363-9.
Safar M.E, Laurent
P. Pulse pressure and arterial
stiffness in rats: comparison with humans. Am
J Physiol Heart Circ Physiol. 2003. 285(4):H1363-9.
Abstract :
In the past, hypertensive rats and men were described with a similar
hemodynamic pattern involving a proportional increase of systolic (S)
and diastolic (D) blood pressure (BP). Nowadays, the enhanced frequency
of systolic hypertension in humans suggests to reinvestigate the classical
similarities and differences between spontaneously hypertensive rats
(SHR) and hypertensive humans.
Old hypertensive rats, with some exception over 50 weeks of age, never
develop systolic hypertension. The possible explanation is that, despite
the development of a pressure-independent increase of large artery
stiffness, a parallel decrease of stroke volume occurs and precedes
congestive heart failure.
Several mechanisms contribute to alter the mechanical arterial properties
in old SHR: endothelial nitrite oxide deficiency and impaired oxidative
stress; development of extracellular matrix, particularly under the
influence of angiotensin II, aldosterone and end-glycosyl products;
increased sodium intake and sensitivity under specific genetic influences.
Both in humans and rats,
these factors contribute to increase arterial stiffness, SBP and
pulse pressure with age, thus reducing cardiovascular longevity and
suggesting to develop novel therapeutic approaches in humans.
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last modified on : 25 oct 2005 |
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